DT: Gregg Berhalter
Chicago Fire4-2-3-1| # | Team | MP | GD | Pts |
|---|---|---|---|---|
| 1 |  Nashville SC | 30 | +41 | 67 |
| 2 |  Inter Miami | 30 | +22 | 55 |
| 3 |  New England | 30 | +8 | 52 |
| 4 | Chicago Fire | 30 | +8 | 48 |
| 5 |  Charlotte | 30 | +8 | 47 |
| 6 |  Philadelphia Union | 30 | +13 | 46 |
| 7 |  Orlando City | 30 | -12 | 41 |
| 8 |  Cincinnati | 30 | -9 | 39 |
| 9 |  New York RB | 30 | -17 | 36 |
| 10 |  Toronto | 30 | -9 | 36 |
| 11 |  Columbus Crew | 30 | -1 | 35 |
| 12 |  New York City | 30 | +2 | 34 |
| 13 |  DC United | 30 | -15 | 33 |
| 14 | Atlanta United | 30 | -14 | 30 |
| 15 |  CF Montréal | 30 | -24 | 25 |
