DT: Laurent Courtois
Columbus Crew3-4-3| # | Team | MP | GD | Pts |
|---|---|---|---|---|
| 1 |  Nashville SC | 34 | +46 | 77 |
| 2 | Inter Miami | 34 | +21 | 60 |
| 3 |  New England | 34 | +8 | 58 |
| 4 |  Chicago Fire | 34 | +10 | 55 |
| 5 |  Charlotte | 34 | +15 | 54 |
| 6 |  Philadelphia Union | 34 | +14 | 50 |
| 7 |  Columbus Crew | 34 | +7 | 47 |
| 8 |  Orlando City | 34 | -15 | 46 |
| 9 |  Cincinnati | 34 | -8 | 46 |
| 10 |  New York RB | 34 | -14 | 42 |
| 11 |  New York City | 34 | +4 | 42 |
| 12 |  Toronto | 34 | -15 | 39 |
| 13 |  Atlanta United | 34 | -17 | 33 |
| 14 |  DC United | 34 | -22 | 33 |
| 15 |  CF Montréal | 34 | -32 | 26 |
